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$99 a month for life for the first 100, about $3.30 a day for both sachets. Then $119 a month.
A daily supplement in a honey sachet, for kids and adults. Saffron two ways, a five-species gut-brain probiotic, vitamin C from acerola cherry and Australian Manuka honey certified MGO 250+. In the trial behind our saffron extract, teens on the same daily amount saw worry and low-mood symptoms fall 33%, against 17% on placebo.* Bright AM and Dream PM for kids and teens 6 to 17. Rise AM and Restore PM for adults, coming soon.
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*Studies conducted on individual ingredients, not on Saffiome as a finished product. Individual results may vary.
Founding Member
$99 a month for life, for the first 100 families.The Kids Day-Night Bundle subscription, about $3.30 a day for both sachets, at a price that holds for as long as you stay. When the 100 places are gone, the price is $119.
Same saffron extract, same honey base, same two moments in the day. Pick the bundle that fits your house.
Kids and teens 6 to 17
Bright AM starts the day, Dream PM ends it. Supports a steady mood through the day and a calmer evening.*
$119 a month on subscription, about $3.97 a day. Or $149 one-off.
Adults
Coming soon
Rise AM starts the day with a gentle green tea lift, Restore PM ends it. Supports a steady mood and better-quality sleep.*
$139 a month on subscription, about $4.63 a day. Or $169 one-off.
The whole house
Coming soon
Both bundles in one order. Four pouches, one delivery, the same routine for everyone.
$229 a month on subscription, about $7.63 a day. Or $289 one-off.
*Studies conducted on individual ingredients, not on Saffiome as a finished product. Individual results may vary. Subscriptions renew every 30 days. Skip, pause or cancel any time. Prices in AUD, GST included.
How it works
The morning sachet starts the day. The evening one ends it, about an hour before bed. Honey texture, no pills, no chewing, no mixing, no food needed, and the same taste every day. Bright AM and Dream PM for kids and teens 6 to 17, Rise AM and Restore PM for adults, coming soon.
One honey sachet when the day starts: affron saffron extract 14 mg, fermented saffron, the xoBiome MoodBalance probiotic and vitamin C from acerola cherry. Supports a steady mood through the day.* Straight from the sachet, off a spoon, or stirred into porridge or yoghurt. Rise AM adds a gentle green tea lift for adults.
One sachet in the early evening, about an hour before bed: the same saffron extract and probiotic, plus a fifth species for the evening, with tart cherry, chamomile and lemon balm. Supports a calmer evening and better-quality sleep.* Restore PM adds passionflower for adults. Your bedtime routine stays exactly as it is.
*Studies conducted on individual ingredients, not on Saffiome as a finished product. Individual results may vary.
What the research shows
Saffiome is built around affron, a standardised saffron extract with eleven published placebo-controlled trials in more than 1,000 people, at the same daily amount the teen trial used: 14 mg to start the day, 14 mg to end it. The studies were on the ingredients, so every number below carries an asterisk.
In an 8-week trial, teens taking 14 mg of affron twice a day, the Saffiome routine, saw a 33% drop in worry and low-mood symptoms against 17% on placebo. More than a third had their scores at least halve, against about one in nine on placebo.*
In a 12-week trial of 202 adults with low mood, 72.3% taking 28 mg of affron a day had a meaningful lift in mood score, against 54.3% on placebo.*
In a 28-day trial of 120 adults with poor sleep, 14 mg of affron before bed improved sleep quality ratings against placebo.*
Eleven published placebo-controlled trials in more than 1,000 people, including the only one in teenagers. Two sachets a day is the same daily amount and the same morning-and-evening split that trial used.*
Vitamin C is the one ingredient in Saffiome that Australian food law has already written the words for. These are those words: it contributes to normal psychological function, it is necessary for normal neurological function, and it contributes to the normal immune system function. Every other benefit on this page comes from a study on an ingredient, which is why those lines carry a note. This one does not. From acerola cherry: 10 mg in every kids' morning sachet, 20 mg in every adult one.
Every species in xoBiome MoodBalance has its own gut-brain research story. The morning sachets carry four. The evening sachets add a fifth. Meet them below.
One fifth of the honey in every sachet is Australian Manuka honey certified MGO 250+, a premium grade tested on every batch. Honey's natural oligosaccharides feed Bifidobacteria and Lactobacilli in laboratory studies, and Manuka has been shown to support Bifidobacterium growth in probiotic milk.*
*Studies conducted on individual ingredients, not on Saffiome as a finished product. Individual results may vary.
The hero ingredient
Saffron has flavoured and coloured Persian food and medicine for about three thousand years. Each crocus flower gives three threads, picked by hand at dawn. We put it in every sachet in two forms.
From flower to sachet
The threads are extracted and standardised so every sachet gets the same amount. Same colour, same measure, every morning and every night.
Whole saffron fermented by a live culture: 100 mg in each kids' sachet (5 mg of saffron) and 200 mg in each adult sachet (10 mg). The rest is the postbiotic, the cells and metabolites the fermentation made. Live cultures from the probiotic, plus what cultures make, in the same sachet.
Grown at Alborea in Albacete, Spain, and extracted with water alone in Madrid.
The base
Every sachet is built on honey: 80% Australian honey and 20% Australian Manuka certified MGO 250+. Not syrup, not sweeteners. Honey is the reason a six-year-old takes the sachet, and it brings its own prebiotic story.
Australian honey
Genuine 100% Australian honey from a family-owned Queensland honey house that has kept bees for more than thirty years. Honey's natural oligosaccharides feed Bifidobacteria and Lactobacilli in laboratory studies, and honey grew ten to a hundred times more lactobacilli than sugar in the lab, with higher counts in animals fed honey rather than sugar.* That is why the base is honey and not syrup.
Honey is also one of the few foods with placebo-controlled trials in young children: in two trials of children kept up by a cough, parents rated their child's sleep better after a spoon of honey before bed than after placebo.*
Sanz 2005; Shamala 2000; Cohen 2012; Paul 2007. About 6 g of natural sugars per sachet, with or without food.
Australian Manuka
One fifth of the honey is Australian Manuka, made by bees working the flowers of Leptospermum, a native tree of Australia and New Zealand. Its grade is a number: MGO 250+ means at least 250 milligrams of methylglyoxal per kilogram, certified on every batch, at the threshold of the grade most people know as UMF 10+.
Manuka is studied for its effect on gut bacteria. In a four-week human trial, 20 g a day of high-grade Manuka left the gut's beneficial bacteria undisturbed, and in the lab Manuka supported Bifidobacterium growth in probiotic milk.* We use it for what it is: a premium, tested honey that belongs in a gut-brain routine.
Wallace 2010; Ibrahim 2026; Cokcetin 2016 for the MGO facts. MGO 250+ describes the Manuka, not the whole sachet.
*Studies conducted on individual ingredients, not on Saffiome as a finished product. Individual results may vary. Laboratory and animal studies unless stated.
xoBiome MoodBalance
The gut and the brain talk all day, through the vagus nerve, through hormones and through the immune system, and the bacteria in the gut join that conversation. xoBiome MoodBalance is a multi-strain probiotic built for it, developed and made on the Gold Coast. The morning sachets carry four species. The evening sachets add a fifth.
The famous pairing
One half of the most-studied psychobiotic pairing in the research. In a 30-day placebo-controlled trial, healthy adults taking L. helveticus with a Bifidobacterium had lower psychological distress scores and lower stress hormone in their urine than the placebo group.*
Messaoudi 2011 (L. helveticus R0052 with B. longum R0175). MoodBalance strain: XXXXXX. Live count per sachet: XXXXXX CFU at end of shelf life.
The vagus nerve study
The species behind the study that started the gut-brain field. In mice, L. rhamnosus changed the brain's calming GABA receptors and lowered stress hormones, and the effect disappeared when the vagus nerve was cut.* In a New Zealand trial of 423 mothers, L. rhamnosus HN001 through pregnancy meant lower low-mood and worry scores after the birth.*
Bravo 2011 (JB-1, mice); Slykerman 2017 (HN001). MoodBalance strain: XXXXXX. Live count per sachet: XXXXXX CFU at end of shelf life.
The one with a trial in kids
The species with a randomised, placebo-controlled trial in autistic children. In Taiwan, 80 boys aged 7 to 15 took L. plantarum PS128 or placebo for four weeks. The trial's three main measures showed no difference against placebo. A difference appeared only in the younger 7 to 12 group, on one secondary measure of opposition and defiance.* In 111 stressed adults, L. plantarum DR7 for 12 weeks lowered stress and worry scores and the stress hormone cortisol against placebo.*
Liu 2019 (PS128); Chong 2019 (DR7). Full study details are in our hub. MoodBalance strain: XXXXXX. Live count per sachet: XXXXXX CFU at end of shelf life.
The memory and mood one
In a 16-week placebo-controlled trial of 80 older adults, B. breve A1 improved memory and thinking scores against placebo, with no adverse events.* In a 4-week trial of 45 adults with low mood, B. breve CCFM1025 improved mood scores against placebo, alongside changes in the gut's tryptophan chemistry.*
Xiao 2020 (A1); Tian 2022 (CCFM1025). MoodBalance strain: XXXXXX. Live count per sachet: XXXXXX CFU at end of shelf life.
The evening species
The GABA maker. Of 91 human gut bacteria tested, L. brevis was the most efficient producer of GABA, the brain's main calming messenger, converting up to 90% of its raw material.* That is why it is in the evening sachet and not the morning one.
Barrett 2012 (DPC6108). MoodBalance strain: XXXXXX. Live count per sachet: XXXXXX CFU at end of shelf life.
Honest note
Probiotic research is strain-specific. The studies above were on named strains of each species. MoodBalance carries these five species; its strain codes (XXXXXX) and live count per sachet (XXXXXX CFU at end of shelf life) are being confirmed with our manufacturer and will be printed here. Until then we tell you the species story and nothing more.
Read the gut-brain research in The Gut-Brain Connection hub.
*Studies on the species, or on particular strains of it, not on xoBiome MoodBalance or on Saffiome. XXXXXX marks a fact we are confirming with our manufacturer before it is printed.
The evening herbs
Both evening sachets carry the same three: tart cherry, chamomile and lemon balm, in a larger amount for adults. Restore PM adds a fourth, passionflower, which is not in the kids' sachet. Each one has its own research, and lemon balm has the most of it in children under 12.
The evening fruit
350 mg in Dream PM (kids), 480 mg in Restore PM (adults). Sour cherry concentrated ten to one, for the compounds that help the body keep tryptophan available in the evening, the building block of its sleep and mood chemistry. In a small trial, adults over 50 slept 84 minutes longer on tart cherry juice than on placebo, and in a 7-day trial of 20 adults, total sleep time and sleep efficiency both rose.*
Losso 2018: eight adults over 50 with insomnia, 240 mL twice a day for two weeks, polysomnography. The trials used juice, so we call it a studied ingredient, not a studied amount.
The evening flower
50 mg in Dream PM (kids), 100 mg in Restore PM (adults). The flower behind Europe's evening tea for centuries. In an 8-week trial, adults taking chamomile extract reported lower worry scores than those on placebo, and a 28-day trial in older adults found better sleep quality ratings than placebo.*
Amsterdam 2009; Adib-Hajbaghery 2017. One 28-day trial in adults with long-term insomnia found no difference on sleep diaries, and we say so.
The calm herb
50 mg in Dream PM (kids), 60 mg in Restore PM (adults). A lemon-scented mint used for calm since the Middle Ages, and the evening herb with the most study in children under 12. In two German studies of more than a thousand children under 12, parents and paediatricians rated a lemon balm and valerian blend as improving restlessness and settling to sleep in most children.*
Müller 2006 (918 children); Gromball 2014 (169 children); Kennedy 2004. The child studies used a blend with valerian and had no placebo group.
The evening vine
60 mg in Restore PM (adults). Not in the kids' sachet. Passiflora incarnata, the flowering vine that European and American herbal traditions kept for evening calm. In a week-long trial of 41 adults, a cup of passionflower tea each evening improved sleep quality ratings against placebo.*
Ngan and Conduit 2011.
*Studies conducted on individual ingredients, not on Saffiome as a finished product. Individual results may vary. Amounts in the sachet are extracts; the trials used juices, teas and larger extract amounts, so these are studied ingredients, not studied amounts.
What to expect
Saffiome is a daily supplement, not a switch. The trials measured change at four, eight and twelve weeks, so that is the honest timeline.
Two sachets, start and end of the day. Most kids take to the honey on day one. The win in the first fortnight is that it happens without a fight, and that it happens every day.
At four weeks, adults with low mood scored better on mood than placebo at 28 mg of affron a day, and adults with poor sleep rated their sleep quality better.*
At eight weeks on 14 mg twice a day, teens aged 12 to 16 reported a 33% drop in worry and low-mood symptoms against 17% on placebo. More than a third had their scores at least halve, against about one in nine on placebo.*
At twelve weeks, 72.3% of adults on 28 mg a day had a meaningful lift in mood score against 54.3% on placebo.* No trial ran longer, so we promise nothing past it. Most families keep the routine because it is easy, not because a calendar says so.
*Studies conducted on individual ingredients, not on Saffiome as a finished product. Individual results may vary.
Where it fits
Saffiome is the morning and night routine that fits around everything your family already does. OT, psych, school supports, medication if you use it: all of that stays. Saffiome is two sachets, one to start the day and one to end it. It does not replace anything, and it does not ask you to change anything else.
If your child takes prescribed medication, show your prescriber the ingredient list before you start. It is all on this page.
Every review from the first 100 families is published as written, good and bad, and each one is verified against an order. The first ones land about three weeks after the first pouches.
From our kitchen table to yours
I'm Regan. My husband and both our girls are neurodivergent, and I'm the one who isn't, which mostly makes me the translator and the one holding the map. I know the mornings, the 3pm crash and the bedtime spiral because they're my life. I designed Burleigh Wagon for my autistic daughter, it became NDIS-fundable, and years of talking to families like ours taught me what actually helps around here. Saffiome is what I wanted for my own kids: real food, studied ingredients, no preservatives, no additives, no junk. One sachet to start the day, one to end it.
Regan Merka, founder. Gold Coast Bulletin Women of the Year 2024.
The range
Every sachet works on its own. Morning and evening together is how we designed it, and the subscription is how most families take it.
The daily supplement for ages 6 to 17: Bright AM starts the day, Dream PM ends it.
Founding Member: $99 a month for life, first 100
Skip, pause or cancel any time.
Coming soon
The daily supplement for adults: Rise AM starts the day, Restore PM ends it.
Skip, pause or cancel any time.
Coming soon
Kids, teens and adults: one daily supplement, four boxes, one pack.
Skip, pause or cancel any time.
Each sachet is available on its own, one-off or on subscription.
$79
or $69 a month on subscription
See it: Bright AM
$79
or $69 a month on subscription
See it: Dream PM
$89
or $79 a month on subscription
See it: Rise AM
$89
or $79 a month on subscription
See it: Restore PMThe morning sachet when the day starts, the evening one about an hour before bed. Bright AM and Dream PM for kids and teens 6 to 17; Rise AM and Restore PM for adults. No food needed, and your bedtime routine stays exactly as it is.
We cannot promise that, and no honest supplement company can. What we can tell you: in two placebo-controlled trials, adults with poor sleep rated their sleep quality better on affron, and the evening sachet carries tart cherry, chamomile and lemon balm, each with sleep or calm studies in adults.* Dream PM goes in the early evening, about an hour before bed, and your bedtime routine stays exactly as it is.
Saffiome is a supplement in a honey sachet: saffron, a probiotic, and evening herbs in the evening sachet. It is designed to sit alongside medication, OT, psych and school supports, because it fits right in with what you already do. Every child is different, so if your child takes prescribed medication, check with your prescriber before adding anything new, and take the ingredient list with you. Every ingredient and amount is on this page.
True, and we will not pretend otherwise. The saffron extract in Saffiome, affron, has eleven published placebo-controlled trials in more than 1,000 people, and the youngest participants were 12 to 16. Saffiome uses the same daily amount that trial used, split the same way. There is no placebo-controlled trial of affron in children under 12. The evening herbs have studies in children under 12, but as a blend with valerian and without a placebo group. Bright AM and Dream PM are for 6 to 17: the teen trial's daily amount is exactly what two kids' sachets deliver. From 18, Rise AM and Restore PM. Every study is listed in The Gut-Brain Connection hub, so you can read them yourself.
Each kids' sachet has about 6 g of sugar and each adult sachet about 7 g, all of it from the honey. Two kids' sachets a day is about 12.5 g, or three teaspoons; two adult sachets about 15 g, or under four. That is the honey doing its job as the food that carries everything else. The morning sachet starts the day and the evening sachet goes about an hour before bed, so it is done before teeth are brushed.
The first 100 families to subscribe to the Kids Day-Night Bundle pay $99 a month, and that price holds for as long as the subscription stays active. If you cancel and come back later, you rejoin at the price of the day.
Stay close
What the research says, what other families do at the start and end of the day, and the odd honest update from Regan. No spam, and you can leave any time.
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